Vitamin D3 5000 iu w/ K2 180mcg 60's

Emerging research highlights the importance of optimal intake of vitamin K and its critical role in maintaining bone and cardiovascular health. Composed of a group of naturally occurring and structurally similar, fat-soluble vitamins, vitamin K is required for the proper utilization of calcium and helps to bind newly absorbed calcium to the bone
matrix. Vitamin K helps maintain bone mineral density by decreasing the activity of osteoclasts, cells that break down bone.

 It also provides critical cardiovascular protection by activating matrix Gla protein (MGP), a potent inhibitor of circulatory calcification.2,3 Along with vitamin D, another key
nutrient required for overall wellness, these two nutrients act
in synergy to support and maintain bone and cardiovascular
health. Current research has found high-concentration
supplementation, at 180 mcg/day, results in improved clinical
results compared to lower-dose supplementation. 
 
This product provides 180 mcg of MenaQ7® PRO, the most widely studied form of vitamin K2 as MK-7, along with 5,000 IU of vitamin D3 for optimal support of bone and cardiovascular health. 

Overview
Calcium and vitamin D are important mediators in bone growth, but vitamin K plays an equally important role. The synthesis of bone growth is dependent on vitamin K
through its carboxylation of osteocalcin, a protein secreted by osteoblasts.

Osteocalcin guides calcium into bones and prevents its absorption into organs, joint spaces and arteries. Vitamin K occurs in two main forms: K1 (phylloquinone), found primarily in the liver, naturally occurs in green leafy vegetables and is considered to be the main dietary source; and K2 (menaquinone), which is a group of related
compounds differentiated by their side chains.
 MK-4 and MK-7 are the two subclasses of K2 most widely studied for their role in bone and cardiovascular health. MK-4 is primarily a metabolic byproduct of K1 while MK-7 is found in small quantities in liver mitochondria and other tissues.
 The MK-7 form is substantially more active, has a longer half-life and accumulates to higher concentrations in serum than vitamin K1.8,9 The different degrees of bioavailability between K1 and K2 are due to differences in structure. The long side-chain of vitamin K2 (specifically MK-7) allows it to bind with fat particles in circulation. This process then allows easier facilitation to soft tissue, bones and arteries. More recently, research has shown that doses of 180 mcg of MK-7 provide greater results when
supporting both bone and cardiovascular health.

The addition of MenaQ7® PRO to this formula is backed by extensive research. Dr. Leon Schurgers , world-renowned expert in vitamin K2 as MK-7 research for cardiovascular and bone health, and his team of research scientists have conducted over 21 clinical trials on MenaQ7® PRO through the University of Maastricht.